At least 57 people were killed by Russian airstrikes and shelling, Ukrainian authorities said on Thursday.
Ukrainian Health Minister Oleh Lyashko said 169 more have been hurt.
Russia launched a full-climb invasion of Ukraine on Thursday, launch of airstrikes on cities and military bases and send troops and tanks from multiple directions in a move that could rewrite the geopolitical world landscape.
Ukraine government pleaded for help as civilians piled into trains and cars to flee.
Lyashko also said on Thursday that Ukrainian authorities were reassigning the country’s health facilities to carry out place for those who need medical assistance because of the hostilities.
Separately, the UN refugee agency said that around 100,000 people fled their homes in Ukraine and several thousand more to have left the country since invasion started.
“We believe that some 100,000 people must have already left their homes and can be moved within the country, and many thousands have crossed international borders”, the United Nations High Commissioner for Shabia Mantoo, UNHCR spokesperson for refugees, told Agence France-Presse (AFP).
UNHCR Filippo Grandi expressed grave concern over the rapid deterioration of the situation like military operations took place across Ukraine and urged neighbors countries keep their borders open for those who seek safety and shelter.
“We continue to closely monitor follow the situation and strengthen our operations in Ukraine and neighboring countries countries“, said the agency.